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Nitric oxide is synthesized within the body from L-arginine, oxygen and Nicotinamide adenine dinucleotide phosphate or NADPH in combination with enzymes. The main function of NO is vasodilatation in which the inner lining of blood vessels utilizes NO to cause the adjacent smooth muscle tissue to relax. This allows the blood vessels to relax, and dilate. The increase in the vessel size as a result of dilatation has a multitude of benefits to several bodily systems, most importantly; the increase in blood allows the nutrients carried by cells to be easily delivered to your tissues with little resistance. By delivering nutrients more efficiently, cell function and growth can be maintained and encouraged. People who experience conditions that negatively impact blood flow such as diabetics (whose blood vessels are narrow enough to cause eventual death of the tissue to which the blood flow is restricted), arteriosclerosis or hardening of the arteries, and high cholesterol typically have an impairment of the NO process; heart attacks, amputations, and kidney failure with dialysis are potential risks these individuals face. The regulation of nutrient delivery by NO is imperative, and its deficit equally profound. NOs increase in blood flow is also experienced with the inflammatory response that triggers NO release to aid in delivering important immune system cells to a site of bacterial or other invasion, and the presence of NO is toxic to bacteria, so post injury recovery is facilitated by NO as well.