L-malate is instrumental in the transportation of NADH to mintochondria for energy production. As we age, we are exposed to a multitude of environmental influences that increase the production of reactive oxygen species, which results in stress exposure, cell damage and dysfunction within the mitochondrial portion. This impacts the production of ATP contributing to energy, decreases protein synthesis, and increases the leakage of a DNA damaging byproduct of cellular exposure to free radicals: peroxide. Peroxide leakage results from the impact of increased intracellular reactive oxygen species upon the cellular membrane that introduces this toxic byproduct into the body. It is associated with multiple forms of functional and physical aging and is dependent upon lipids to deliver its destruction within the cell. Vulnerability of cells to stressors increases with age due to the decrease of antioxidants within the body. L-malate studies indicate that oxidative stress is reversed through L-malate supplementation by increasing the levels of glutathione, one of the most powerful antioxidant s, by up to 60%, which impacts the rate of cellular aging, and maintenance of cell function. L-malate also increases cellular metabolism which decreases the lipids available to transport the precursors to premature aging, or peroxide.